Koenig JQ, Mar TF, Allen RW, Jansen K, Lumley T, Sullivan JH, Trenga CA, Larson TV, and Liu L-JS. 2005. Pulmonary Effects of Indoor- and Outdoor-Generated Particles in Children with Asthma. Environmental Health Perspectives (EHP), 113 (4): 499-503.
This study investigated, with measurements and statistical models, the potentially different respiratory health effects of particles generated from various sources indoors and outdoors on 19 children with doctor-diagnosed asthma. Fine particles, or PM2.5, was the exposure variable assessed. The outcome variable measured was exhaled nitric oxide (eNO), which is a biological marker of inflammation of the airways. Among asthmatic study children not using corticosteroid medications, the model results suggested an increase of 10 micrograms per cubic meter of outdoor-generated PM2.5 was statistically significantly associated with about a 5 ppb increase in eNO. This study suggested personal exposure to outdoor-generated PM2.5, like from mobile sources, may be more potent (and toxic) per unit mass than particles generated inside homes or schools.
To read the abstract to this article, please go to:
http://ehp.niehs.nih.gov/docs/2005/7511/abstract.html
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