Study in JACI by Gruchalla et al on results of home environment dust sample-- relative impacts of asthma triggers / allergens-- from USA Inner-City Asthma Study
Gruchalla RS, Pongracic J, Plaut M, Evans III R, Visness CM, Walter M, Crain EF, Kattan M, Morgan WJ, Steinbach S, Stout J, Malindzak G, Smartt E, Mitchell H.
2005.
"Inner City Asthma Study: Relationships among sensitivity, allergen exposure, and asthma morbidity."
Journal of Allergy and Clinical Immunology, 115 (3): 478-84
This paper continues the reporting of results from a multi-year, eight site nationwide study of inner-city children with asthma including the Bronx and Manhattan (New York City), Boston, Chicago, Dallas, Seattle, and Tucson. These results pertain to 937 children diagnosed with asthma between the ages of 5-11 who had allergen skin prick tests. In addition, dust samples from each child's bedroom were collected and analyzed for dust mite allergens (Der p 1 and Der f 1), cockroach allergen (Bla g 1), cat allergen (Fel d 1), and dog allergen (Can f 1). The researchers reported study site-specific differences, i.e. geographical (spatial) variability, in results from the skin test sensitivities. The researchers also reported the allergen levels in dust samples varied, by study site and across study sites, by type of housing-- cockroach allergen levels were higher in high-rise apartments and levels of both dust mite allergens were higher in detached homes (i.e. homes for individual families). Cockroach allergen sensitivity and exposure to elevated levels of cockroach allergen had a relatively greater adverse impact on study children than the other measured allergens. Adverse effects included the number of reported asthma symptom days and the number of days absent from school.
For the abstract and full text to this paper, please go to:
http://www2.us.elsevierhealth.com/scripts/om.dll/serve?action=searchDB&searchDBfor=art&artType=abs&id=as0091674904032270&nav=abs
Also, on our website we summarized another peer-reviewed article about interventions in the home environment evaluated in this study:
Study in NEJM by Morgan et al: study in multiple U.S. inner cities supports the important role of interventions to reduce the prevalence and levels of environmental triggers of childhood asthma in homes, which complements clinical management of asthma
New results from study in multiple U.S. inner cities supports the important role of interventions to reduce the prevalence and levels of environmental triggers of childhood asthma in homes, which complements clinical management of asthma
Morgan WJ, Crain EF, Gruchalla RS, O’Connor GT, Kattan M, Evans III R, Stout J, Malindzak G, Smartt E, Plaut M, Walter M, Vaughn B, Mitchell H, for the Inner-City Asthma Study Group. 2004 (September 9).
"Results of a Home-Based Environmental Intervention among Urban Children with Asthma."
New England Journal of Medicine, 351 (11): 1068-80.
For a summary of this research paper, please go to: http://www.calasthma.org/resources/show_resource/428/
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